2025:
“Benchmarking SILAC Proteomics Workflows and Data Analysis Platforms“.Frankenfield, A.M., Yang, K.L., Mazli, A., Shih, J., Yu, F., Lo, E., Nesvizhskii, A.I., Hao, L., Molecular & Cellular Proteomics,
24 (6), 2025.
“Evaluating sample normalization methods for MS-based multi-omics and the application to a neurodegenerative mouse model“, Lee, G.B., Yang, C., Hu, F., Hao, L., Analyst, 150, 1271, 2025.
“Overcoming Analytical Challenges in Proximity Labeling Proteomics“, Li, H., Mazli, A, Hao, L., Journal of Mass Spectrometry, 60(5), p.e5134, 2025 (Journal Front Cover).
“TMEM106B deficiency leads to alterations in lipid metabolism and obesity in theTDP-43 knock-in mouse model”, Yang, C., Lee, G., Hao, L., Hu, F., Communications Biology, 2025, 8 (1), 315.
2024:
“Contaminant Spot Check and Removal Assay (ContamSPOT) for Mass Spectrometry Analysis”, Smeriglio, N., Li, H., Mazli, A., Bendel, K., Hao, L., Analytical Chemistry, 96, 6, 2574-2581, 2024.
“Multiomics Evaluation of Human iPSCs and iPSC-Derived Neurons”. Lee, G.B, Mazli, A. Hao, L., Journal of Proteome Research, 23 (8), 3149, 2024.
“Absolute Quantification of Amine Metabolites in Human Cerebrospinal Fluid via MS1-centric Isotopic N,N-dimethyl-Leucine (iDiLeu) Labeling”, Riusech,O., Hao, L., Li, L., Analytical and Bioanalytical Chemistry, 2024, 1-9.
“Renal Autocrine Neuropeptide FF Signaling Regulates Blood Pressure“, Lee, H., Amatya, B., Villar, V. A. M., Asico, L. D., Jeong, J. K., Feranil, J., Moore, S.C., Zheng, X., Bishop, M., Gomes, J., Polzin, J., Smeriglio, N., Castro, P., Armando, I., Felder, R., Hao, L., Jose, P. A., Scientific Reports, 2024, 14, 15407.
2023:
“Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons”. Hasan, S., Fernandopulle, M., Humble, S., Frankenfield, A., Li, H., Prestil, R., Johnson, K., Ryan, B., Wade-Martins, R., Ward, M. E., Hao, L., Molecular Neurodegeneration, 18, 87, 2023. (IF 15.8).
“Benchmarking and Automating the Biotinylation Proteomics Workflow”. Li, H., Smeriglio, N., Ni, J., W. Yan, Sekine, S., Hao, L., Preprint.
2022:
“Protein Contaminants Matter: Building Universal Protein Contaminant Libraries for DDA & DIA Proteomics“. Frankenfield, A., Ni, J., Ahmed,M., Hao, L., Journal of Proteome Research, 21, 9, 2104–2113 2022. (Journal Front Cover)
“Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics“. A. Frankenfield, A., Ni, J., Hao, L., Journal of Visualized Experiments, (184), e64132, 2022.
“Integrated Proteomic and Metabolomic Analyses of the Mitochondrial Neurodegenerative Disease MELAS“. Li, H., Uittenbogaard, M., Navarro, R., Ahmed, M., Gropman, A., Chiaramello, A., Hao, L., Molecular Omics, 18, 196-205, 2022.
2021:
“Thiol-Cleavable Biotin for Chemical and Enzymatic Biotinylation and Its Application to Mitochondrial TurboID Proteomics“. Li, H., Frankenfield, A.M., Houston, R., Sekine, S., and Hao, L., Journal of the American Society for Mass Spectrometry, 32, 9, 2358–2365, 2021. (Journal Front Cover)
“Clinical Insights into Mitochondrial Neurodevelopmental and Neurodegenerative Disorders: Their Biosignatures from Mass Spectrometry-Based Metabolomics”. Li, H., Uittenbogaard, M., Hao, L., and Chiaramello, A., Metabolites, 11 (4), 233, 2021.
“Determining the Ethanol Concentrations in Ethyl Alcohol-Based Hand Sanitizers with Different Expiration Dates Using Fourier-Transform Infrared Spectroscopy (FT-IR)”. Shlafstein, M., Hannah, E., Hao, L., ChemRxiv, Preprint, Cambridge: Cambridge Open Engage; 2021.
“Determining the Acetic Acid Concentration in White Vinegar: An At-Home Undergraduate Chemistry Experiment During the COVID-19 Pandemic.” Parel, P., Burnett, L., Geoffroy, M., Parel, J., Hao, L.. ChemRxiv, Preprint, Cambridge: Cambridge Open Engage; 2021.
2020:
“Development and Comparative Evaluation of Endolysosomal Proximity Labeling-based Proteomic Methods in Human iPSC-derived Neurons“. Frankenfield, A.M., Fernandopulle, M.S., Hasan, S., Ward, M.E. and Hao, L., Analytical Chemistry, 92 (23), 15437-15444, 2020.
Selected Publications prior to 2019:
Sliter, D.A., Martinez, J., Hao, L., Chen, X., Sun, N., Fischer, T.D., Burman, J.L., Li, Y., Zhang, Z., Narendra, D.P. and Cai, H., Borsche, M., Klein, C., Youle., R.,”Parkin and PINK1 mitigate STING-induced inflammation“. Nature, 561(7722), 258-262. 2018.
Liao, Y.C., Fernandopulle, M.S., Wang, G., Choi, H., Hao, L., Drerup, C.M., Patel, R., Qamar, S., Nixon-Abell, J., Shen, Y. and Meadows, W., Vendruscolo, M., Knowles, T., Nelson, M., Czekalska, M.A., Musteikyte, G., Gachechiladze, M., Stepohen, C., Pasolli, A., Forrest, L., George-Hyslop, P., Lippincott-Schwartz, J., Ward, M., “RNA granules hitchhike on lysosomes for long-distance transport, using annexin A11 as a molecular tether.” Cell, 179(1), 147-164. 2019.
Lu, J., Zhong, X., Liu, H., Hao, L., Huang, C.T., Sherafat, M.A., Jones, J., Ayala, M., Li, L. and Zhang, S.C., “Generation of serotonin neurons from human pluripotent stem cells.” Nature Biotechnology, 34(1), 89. 2016.
Hao, L., Zhu, Y., Wei, P., Johnson, J., Buchberger, A., Frost, D., Kao, W.J. and Li, L., “Metandem: An online software tool for mass spectrometry-based isobaric labeling metabolomics“. Analytica Chimica Acta, 1088, 99-106, 2019.
Vargas, J. N. S., Wang, C., Bunker, E., Hao, L., Maric, D., Schiavo, G., … & Youle, R. J. “Spatiotemporal control of ULK1 activation by NDP52 and TBK1 during selective autophagy“. Molecular cell, 74(2), 347-362. 2019.
Hao, L., Wang, J., Page, D., Asthana, S., Zetterberg, H., Carlsson, C., … & Li, L. “Comparative Evaluation of MS-based Metabolomics Software and Its Application to Preclinical Alzheimer’s Disease“. Scientific Reports, 8, 2018.
Hao, L., Johnson, J., Lietz, C.B., Buchberger, A., Frost, D., Kao, W.J. and Li, L., “Mass defect-based N, N-dimethyl leucine labels for quantitative proteomics and amine metabolomics of pancreatic cancer cells“. Analytical Chemistry, 89(2), 1138-1146. 2017. (Journal Front Cover)
Liu, F., Ma, F., Wang, Y., Hao, L., Zeng, H., Jia, C., … & Chen, G. “PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis“. Nature cell biology, 19(11), 1358, 2017.
Thomas, S., Hao., L, Ricke, W., Li, L. “Biomarker Discovery in Mass Spectrometry-based Urinary Proteomics.” PROTEOMICS-Clinical Applications 10(4), 358, 2016. (Cover article)
Hao, L., Zhong, X., Greer, T., Ye, H., Li, L. “Relative Quantification of Amine- Containing Metabolites using Isobaric N,N-Dimethyl Leucine (DiLeu) Reagents via LC-ESI- MS/MS and CE-ESI-MS/MS.” Analyst, 140, 467, 2015.