Trace Software for Ultrasensitive Mass Spectrometry:

  • Software (see Supplementary Information) : Z. Liu, E. P. Portero, Y. Jian, Y. Zhao, R. M. Onjiko, C. Zeng*, and P. Nemes*, Trace, Machine learning of signal images for trace-sensitive mass spectrometry: A case study from single-cell metabolomics, Anal. Chem. 2019, 91, 5768–5776, DOI: 10.1021/acs.analchem.8b05985, Download
  • MS Data: Single-cell metabolomics: MetabolomicsWorkbench Project DOI:

Reviews in Single-cell Mass Spectrometry (In Reversed Chronological Order)

  1. M. S. Nisar and X. Zhao*, High resolution mass spectrometry for single cell analysis, Int. J. Mass Spectrom. 2020, 450, 116302,
  2. X. K. Lun and B. Bodenmiller*, Profiling cell signaling networks at single-cell resolution, Mol. Cell. Proteom. 2020, 19, 744-756,
  3. S. A. Moshkovskii*, A. A. Lobas, and M. V. Gorshkov, Single cell proteogenomics—immediate prospects, Biochemistry 2020, 85, 140-146,
  4. V. Marx*, A dream of single-cell proteomics, Nat. Methods 2019, 16, 809-812,
  5. T. M. J. Evers, M. Hochane, S. J. Tans, R. M. A. Heeren, S. Semrau, P. Nemes, and A. Mashaghi*. Deciphering metabolic heterogeneity by single-cell analysis, Anal. Chem. 2019, 91, 13314-13323,
  6. E. K. Neumann, T. D. Do, T. J. Comi, and J. V. Sweedler*, Exploring the fundamental structures of life: non‐targeted, chemical analysis of single cells and subcellular structures, Angew. Chem. Int. Ed. 2019, 58, 9348 -9364,
  7. L. Yin, Z. Xhang, Y. Liu, Y. Gao*, and J. Gu*, Recent advances in single-cell analysis by mass spectrometry, Analyst 2019, 144, 824-845,
  8. X. Ou, P. Chen, and B. F. Liu*, Single-cell analysis with microfluidic devices, Anal. Sci. 2019, 35, 609-618,
  9. I. S. Gilmore*, S. Heiles, and C. L. Pieterse, Metabolic imaging at the single-cell scale: recent advances in mass spectrometry imaging, Annu. Rev. Anal. Chem. 2019, 12, 201-224,
  10. K. D. Duncan, J. Fyrestam, and I. Lanekoff*, Advances in mass spectrometry based single-cell metabolomics, Analyst 2019, 144, 782-793,
  11. K. DeLaney, C. S. Sauer, N. Q. Vu, and L. Li*, Recent advances and new perspectives in capillary electrophoresis-mass spectrometry for single cell “Omics”, Molecules 2019, 24, 42,
  12. S. P. Couvillion, Y. Zhu, G. Nagy, J. N. Adkins, C. Ansong, R. S. Renslow, P. D. Piehowski, Y. M. Ibrahim, R. T. Kelly, and T. O. Metz*,  New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells, Analyst 2019, 144, 794-807,
  13. Y. Liu, X. Chen, Y. Zhang, and J. Liu*, Advancing single-cell proteomics and metabolomics with microfluidic technologies, Analyst 2019, 144, 846‐858,
  14. X. Shao, L. Weng, M. Gao, and X. Zhang*, Single-cell analysis for proteome and related researches, Trends Anal. Chem. 2019, 120, 115666,
  15. M. Qi, M. C. Philip, N. Yang, and J. V. Sweedler*, Single cell neurometabolomics, ACS Chem. Neurosci. 2018, 9, 40-50, 10.1021/acschemneuro.7b00304
  16. H. Specht and N. Slavov*, Transformative opportunities for single-cell proteomics, J. Proteome Res. 2018, 17, 2565–2571,
  17. E. Levy and N. Slavov*, Single cell protein analysis for systems biology, Essays Biochem. 2018, 62, 595-605,
  18. L. W. Zhang and A. Vertes*, Single‐cell mass spectrometry approaches to explore cellular heterogeneity, Angew. Chem. Int. Ed. 2018, 57, 4466-4477,
  19. Y. J. Lee and R. L. Hansen*, High-spatial resolution mass spectrometry imaging: toward single cell metabolomics in plant tissues, Chem. Rec. 2018, 18, 65-77, 10.1002/tcr.201700027
  20. M. Mondal, R. Liao, and J. Gao*, Highly multiplexed single-cell protein analysis, Chem. Eur. J. 2018, 24, 7083-7091,
  21. T. J. Comi, T. D. Do, S. S. Rubakhin, and J. V. Sweedler*, Categorizing cells on the basis of their chemical profiles: progress in single-cell mass spectrometry, J. Am. Chem. Soc. 2017, 139, 3920–3929,
  22. S. Emara, S. Amer, A. Ali, Y. Abouleia, A. Oga, and T. Masujima*, Single-cell metabolomics, Adv. Exp. Med. Biol. 2017, 965, 323-343,
  23. Y. Y. Yang*, Y. Y. Huang, J. H. Wu, N. Liu, J. W. Deng*, and T.G. Luan*, Single-cell analysis by ambient mass spectrometry, Trends Anal. Chem. 2017, 90, 14-26,
  24. H. Jungnickel, P. Laux, and A. Luch*, Time-of-flight secondary ion mass spectrometry (ToF-SIMS): a new tool for the analysis of toxicological effects on single cell level, Toxics 2016, 4, 5,
  25. A. N. Polat and N. Ozlu*, Towards single-cell LC-MS phosphoproteomics, Analyst 2014, 139, 4733-4749,
  26. R. Zenobi*, Single-cell metabolomics: analytical and biological perspectives, Science 2013, 342, 1243259,
  27. M. K. Passarelli and A. G. Ewing*, Single-cell imaging mass spectrometry, Curr. Opin. Chem. Biol. 2013, 17, 854-859, 10.1016/j.cbpa.2013.07.017
  28. R. Trouillon, M. K. Passarelli, J. Wang, M. E. Kurczy, and A. G. Ewing*, Chemical analysis of single cells, Anal. Chem. 2013, 85, 522-542,
  29. S. S. Rubakhin, E. J. Lanni, and J. V. Sweedler*, Progress toward single cell metabolomics, Curr. Opin. Biotech. 2013, 24, 95-104,
  30. E. J. Lanni, S. S. Runakhin, and J. V. Sweedler*, Mass spectrometry imaging and profiling of single cells, J. Proteom. 2012, 75, 5036-5051,
  31. M. Heinemann and R. Zenobi*, Single cell metabolomics, Curr. Opin. Biotech. 2011, 22, 26-31,
  32. S. S. Rubakhin, E. V. Romanova, P. Nemes, and J. V. Sweedler*, Profiling metabolites and peptides in single cells, Nat. Methods 2011, 8, S20–S29,
  33. K. J. Boggio, E. Obasuyi, K. Sugino, S. B. Nelson, N. Y. R. Agar, and J. N. Agar*, Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact, Expert Rev. Proteomic. 2011, 8, 591-604,
  34. J. D. Watrous and P. C. Dorrestein*, Imaging mass spectrometry in microbiology, Nat. Rev. Microbiol. 2011, 9, 683-694,
  35. D. Wang and S. Bodovitz*, Single cell analysis: the new frontier in ‘omics’, Trends Biotechnol. 2010, 28, 281-290,
  36. T. Masujima*, Live single-cell mass spectrometry, Anal. Sci. 2009, 25, 953-960,