Amy Schumer is one of the most well-known comedians of her generation, renowned for her fearless humor and candid approach to personal topics. Over the years, she has built a reputation for being refreshingly honest about the ups and downs of her life, including her journey with weight loss. Recently, Amy Schumer has shared her personal weight loss story with her fans, revealing her struggles with various weight loss medications, including Ozempic, and her new approach to health and wellness. This is her story of transformation—physical, mental, and emotional.
The Beginning: A Journey Full of Struggles
Amy Schumer, who has always been open about her body and self-image, faced her own struggles with weight and health. In her early career, she often joked about her appearance, using humor to deflect the insecurities many of us feel when it comes to body image. However, as Schumer’s career evolved, so did her awareness of her health.
In recent years, she began to feel the pressure, not just from her own feelings about her body, but from the demands of Hollywood and society’s expectations of women in the public eye. It wasn’t just about fitting into a certain dress size or looking a specific way for a role—Schumer felt the urge to take charge of her own health for the sake of her well-being and long-term happiness.
“I had to face the fact that I wasn’t taking care of my body,” Schumer said in a 2025 interview with People. “Being honest about that with myself was hard. But I knew I had to do it for my son, my career, and my own peace of mind.”
The Decision to Try Weight Loss Medications
Schumer’s first step toward weight loss involved consulting with medical professionals about potential solutions. Like many people, she was introduced to medications designed for weight loss, including Ozempic, a medication used to treat Type 2 diabetes but also known for its weight loss side effects. Schumer took Ozempic for several months and initially saw rapid results—losing 30 pounds quickly.
However, the experience wasn’t all positive. “I lost 30 pounds so quickly. I looked great, but I felt horrible. I couldn’t lift my head off the pillow. It was just too much for my body,” Schumer admitted during an appearance on The Howard Stern Show.
Despite the impressive weight loss, the negative side effects were too severe for Schumer to continue using the medication. The nausea and fatigue were so intense that it left her bedridden at times, forcing her to reassess the path she was on.
A New Approach: Mounjaro and Mindful Weight Loss
After her experience with Ozempic, Schumer decided to try a new medication, Mounjaro, which she described as having a much better experience with. Unlike Ozempic, which left her feeling drained and sick, Mounjaro seemed to have fewer side effects, making it a more tolerable option for her. Schumer shared her positive experience with Mounjaro on Instagram in March 2025, noting that she felt better both physically and emotionally during her weight loss journey with this new medication.
“I’ve been feeling so much better on Mounjaro. It’s like a night-and-day difference from my previous experience,” Schumer posted, expressing her relief at finding something that worked for her body without causing debilitating side effects.
However, Schumer has also emphasized that the weight loss medications are only one part of the story. Her ultimate transformation wasn’t just about taking a pill or relying on injections—it was about taking ownership of her health and mindset.
The Emotional Transformation: Self-Awareness and Healing
While the physical changes were undoubtedly important to Schumer, the emotional transformation that came with her weight loss was just as significant. She didn’t just want to lose weight; she wanted to feel better about herself, free from the insecurities and self-doubt that had plagued her for years.
“Losing weight doesn’t just mean feeling better in your body—it’s about feeling better in your heart and mind,” Schumer reflected. “The biggest shift for me wasn’t just losing the weight. It was learning to love myself no matter what I looked like.”
Throughout this process, Schumer has worked on her emotional health as much as her physical health. The comedian, known for her raw humor, has shared openly about the mental health challenges she faced, including battling anxiety and learning to manage the stress of being in the public eye.
Self-Reflection and Support
Schumer’s journey has also involved seeking therapy and engaging in mindfulness practices to help her manage anxiety. She credits her emotional growth to these tools, which have allowed her to become more self-aware and handle the ups and downs of life more effectively.
“I’ve done a lot of emotional work in therapy, and I think that’s just as important as the physical work. It’s all about balance,” Schumer explained in an interview with Today.
Her experience mirrors that of many who embark on a health transformation—not just focusing on diet or exercise but working on mental health and self-acceptance. Schumer has also shared her struggles with the pressures of social media, acknowledging how difficult it can be to compare oneself to others, especially when constantly in the public eye.
The Results: A New Perspective on Health and Happiness
As of early 2025, Schumer has lost significant weight, but more importantly, she has gained a new perspective on what it means to be healthy. The comedian is quick to remind her fans that weight loss is not a one-size-fits-all process, and what works for one person might not work for another.
“I feel amazing now, and it wasn’t just the medication. It was finding the right balance of healthy choices and emotional support,” Schumer says, reflecting on her transformative journey. “I know that I’ll always have ups and downs, but now I have the tools to deal with them.”
Her transformation is not just about the number on the scale but about reclaiming control over her own health. Schumer continues to inspire others to take ownership of their wellness journey, acknowledging that it’s okay to ask for help, whether through medication, therapy, or simply being kinder to oneself.
An Ongoing Journey
Amy Schumer’s weight loss journey has been full of ups and downs, but it has ultimately led to a place of greater self-awareness and self-love. She’s a testament to the fact that health is a multifaceted journey, and while weight loss can be a part of it, mental and emotional well-being are just as important.
Her story is a reminder that it’s okay to ask for help, to try new things, and to adjust your path along the way. Schumer’s journey isn’t just about losing weight—it’s about finding happiness, health, and balance in all areas of life. Her openness about the struggles she’s faced has created an important dialogue about body image, mental health, and the complexities of weight loss. As Schumer herself says, “It’s not about perfection. It’s about progress.”