Resources

Trace Software for Ultrasensitive Mass Spectrometry:

  • Software (see Supplementary Information) : Z. Liu, E. P. Portero, Y. Jian, Y. Zhao, R. M. Onjiko, C. Zeng*, and P. Nemes*, Trace, Machine learning of signal images for trace-sensitive mass spectrometry: A case study from single-cell metabolomics, Anal. Chem. 2019, 91, 5768–5776, DOI: 10.1021/acs.analchem.8b05985, Download
  • MS Data: Single-cell metabolomics: MetabolomicsWorkbench Project DOI: https://doi.org/10.21228/M80Q2W.

Reviews in Single-cell Mass Spectrometry (In Reversed Chronological Order)

  1. M. S. Nisar and X. Zhao*, High resolution mass spectrometry for single cell analysis, Int. J. Mass Spectrom. 2020, 450, 116302, https://doi.org/10.1016/j.ijms.2020.116302
  2. X. K. Lun and B. Bodenmiller*, Profiling cell signaling networks at single-cell resolution, Mol. Cell. Proteom. 2020, 19, 744-756, https://doi.org/10.1074/mcp.R119.001790
  3. S. A. Moshkovskii*, A. A. Lobas, and M. V. Gorshkov, Single cell proteogenomics—immediate prospects, Biochemistry 2020, 85, 140-146, https://doi.org/10.1134/S0006297920020029
  4. V. Marx*, A dream of single-cell proteomics, Nat. Methods 2019, 16, 809-812, https://doi.org/10.1038/s41592-019-0540-6
  5. T. M. J. Evers, M. Hochane, S. J. Tans, R. M. A. Heeren, S. Semrau, P. Nemes, and A. Mashaghi*. Deciphering metabolic heterogeneity by single-cell analysis, Anal. Chem. 2019, 91, 13314-13323, https://doi.org/10.1021/acs.analchem.9b02410
  6. E. K. Neumann, T. D. Do, T. J. Comi, and J. V. Sweedler*, Exploring the fundamental structures of life: non‐targeted, chemical analysis of single cells and subcellular structures, Angew. Chem. Int. Ed. 2019, 58, 9348 -9364, https://doi.org/10.1002/anie.201811951
  7. L. Yin, Z. Xhang, Y. Liu, Y. Gao*, and J. Gu*, Recent advances in single-cell analysis by mass spectrometry, Analyst 2019, 144, 824-845, https://doi.org/10.1039/C8AN01190G
  8. X. Ou, P. Chen, and B. F. Liu*, Single-cell analysis with microfluidic devices, Anal. Sci. 2019, 35, 609-618, https://doi.org/10.2116/analsci.19R001
  9. I. S. Gilmore*, S. Heiles, and C. L. Pieterse, Metabolic imaging at the single-cell scale: recent advances in mass spectrometry imaging, Annu. Rev. Anal. Chem. 2019, 12, 201-224, http://doi.org/10.1146/annurev-anchem-061318-115516
  10. K. D. Duncan, J. Fyrestam, and I. Lanekoff*, Advances in mass spectrometry based single-cell metabolomics, Analyst 2019, 144, 782-793, https://doi.org/10.1039/C8AN01581C
  11. K. DeLaney, C. S. Sauer, N. Q. Vu, and L. Li*, Recent advances and new perspectives in capillary electrophoresis-mass spectrometry for single cell “Omics”, Molecules 2019, 24, 42, https://doi.org/10.3390/molecules24010042
  12. S. P. Couvillion, Y. Zhu, G. Nagy, J. N. Adkins, C. Ansong, R. S. Renslow, P. D. Piehowski, Y. M. Ibrahim, R. T. Kelly, and T. O. Metz*,  New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells, Analyst 2019, 144, 794-807, https://doi.org/10.1039/C8AN01574K
  13. Y. Liu, X. Chen, Y. Zhang, and J. Liu*, Advancing single-cell proteomics and metabolomics with microfluidic technologies, Analyst 2019, 144, 846‐858, https://doi.org/10.1039/c8an01503a
  14. X. Shao, L. Weng, M. Gao, and X. Zhang*, Single-cell analysis for proteome and related researches, Trends Anal. Chem. 2019, 120, 115666, https://doi.org/10.1016/j.trac.2019.115666
  15. M. Qi, M. C. Philip, N. Yang, and J. V. Sweedler*, Single cell neurometabolomics, ACS Chem. Neurosci. 2018, 9, 40-50, https://doi.org/ 10.1021/acschemneuro.7b00304
  16. H. Specht and N. Slavov*, Transformative opportunities for single-cell proteomics, J. Proteome Res. 2018, 17, 2565–2571, https://doi.org/10.1021/acs.jproteome.8b00257
  17. E. Levy and N. Slavov*, Single cell protein analysis for systems biology, Essays Biochem. 2018, 62, 595-605, http://doi.org/10.1042/EBC20180014
  18. L. W. Zhang and A. Vertes*, Single‐cell mass spectrometry approaches to explore cellular heterogeneity, Angew. Chem. Int. Ed. 2018, 57, 4466-4477, https://doi.org/10.1002/anie.201709719
  19. Y. J. Lee and R. L. Hansen*, High-spatial resolution mass spectrometry imaging: toward single cell metabolomics in plant tissues, Chem. Rec. 2018, 18, 65-77, https://doi.org/ 10.1002/tcr.201700027
  20. M. Mondal, R. Liao, and J. Gao*, Highly multiplexed single-cell protein analysis, Chem. Eur. J. 2018, 24, 7083-7091, https://doi.org/10.1002/chem.201705014
  21. T. J. Comi, T. D. Do, S. S. Rubakhin, and J. V. Sweedler*, Categorizing cells on the basis of their chemical profiles: progress in single-cell mass spectrometry, J. Am. Chem. Soc. 2017, 139, 3920–3929, https://doi.org/10.1021/jacs.6b12822
  22. S. Emara, S. Amer, A. Ali, Y. Abouleia, A. Oga, and T. Masujima*, Single-cell metabolomics, Adv. Exp. Med. Biol. 2017, 965, 323-343, https://doi.org/10.1007/978-3-319-47656-8_13
  23. Y. Y. Yang*, Y. Y. Huang, J. H. Wu, N. Liu, J. W. Deng*, and T.G. Luan*, Single-cell analysis by ambient mass spectrometry, Trends Anal. Chem. 2017, 90, 14-26, https://doi.org/10.1016/j.trac.2017.02.009
  24. H. Jungnickel, P. Laux, and A. Luch*, Time-of-flight secondary ion mass spectrometry (ToF-SIMS): a new tool for the analysis of toxicological effects on single cell level, Toxics 2016, 4, 5, https://doi.org/10.3390/toxics4010005
  25. A. N. Polat and N. Ozlu*, Towards single-cell LC-MS phosphoproteomics, Analyst 2014, 139, 4733-4749, https://doi.org/10.1039/C4AN00463A
  26. R. Zenobi*, Single-cell metabolomics: analytical and biological perspectives, Science 2013, 342, 1243259, https://doi.org/10.1126/science.1243259
  27. M. K. Passarelli and A. G. Ewing*, Single-cell imaging mass spectrometry, Curr. Opin. Chem. Biol. 2013, 17, 854-859, https://doi.org/ 10.1016/j.cbpa.2013.07.017
  28. R. Trouillon, M. K. Passarelli, J. Wang, M. E. Kurczy, and A. G. Ewing*, Chemical analysis of single cells, Anal. Chem. 2013, 85, 522-542, https://doi.org/10.1021/ac303290s
  29. S. S. Rubakhin, E. J. Lanni, and J. V. Sweedler*, Progress toward single cell metabolomics, Curr. Opin. Biotech. 2013, 24, 95-104, https://doi.org/10.1016/j.copbio.2012.10.021
  30. E. J. Lanni, S. S. Runakhin, and J. V. Sweedler*, Mass spectrometry imaging and profiling of single cells, J. Proteom. 2012, 75, 5036-5051, https://doi.org/10.1016/j.jprot.2012.03.017
  31. M. Heinemann and R. Zenobi*, Single cell metabolomics, Curr. Opin. Biotech. 2011, 22, 26-31, https://doi.org/10.1016/j.copbio.2010.09.008
  32. S. S. Rubakhin, E. V. Romanova, P. Nemes, and J. V. Sweedler*, Profiling metabolites and peptides in single cells, Nat. Methods 2011, 8, S20–S29, https://doi.org/10.1038/nmeth.1549
  33. K. J. Boggio, E. Obasuyi, K. Sugino, S. B. Nelson, N. Y. R. Agar, and J. N. Agar*, Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact, Expert Rev. Proteomic. 2011, 8, 591-604, https://doi.org/10.1586/epr.11.53
  34. J. D. Watrous and P. C. Dorrestein*, Imaging mass spectrometry in microbiology, Nat. Rev. Microbiol. 2011, 9, 683-694, https://doi.org/10.1038/nrmicro2634
  35. D. Wang and S. Bodovitz*, Single cell analysis: the new frontier in ‘omics’, Trends Biotechnol. 2010, 28, 281-290, https://doi.org/10.1016/j.tibtech.2010.03.002
  36. T. Masujima*, Live single-cell mass spectrometry, Anal. Sci. 2009, 25, 953-960, http://doi.org/10.2116/analsci.25.953